Pseudoproline libraries for tuning inhibitors of SH3 domain mediated protein-protein interactions

摘要

Specific protein-protein interactions are essential facets in cellular communication and the formation and specific assembly of multicomponent protein complexes often is regulated by binding to proline (Pro)-rich peptide sequences.Pro-rich ligands adopt a left-handed polyproline II helical conformation (PPII,all trans amide bonds) and bind to a highly conserved patch of aromatic amino acids of e.g.Src homology (SH3) domains.