Thrombin receptor aromatic residues for edge-to-face CH/pi interaction with ligand Phe-2-phenyl group

摘要

Sering protease thrombin plays an important role in blood coagulation and possesses a specific receptor in the platelets.When thrombin cleaves the peptide bond between Arg-41 and Ser-42 in the N-terminal segment of receptor,the newly exposed N-terminal peptide segment binds to the receptor itself as a tethered ligand which activates the receptor.