Covalent and non-covalent oligomerization of the transmembrane alpha-helix 4 from the cystic fibrosis conductance regulator

摘要

Cystic fibrosis (CF) is an autosomal recessive disease that affects approximately 1 in 2000 people in Canada and the United State.The disease arises through mutations to the cystin fibrosis transmembrane conductance regulator protein (CFIR).