Effect of Vaccination with an Inactivated Autogenous Vaccine on the Course of an Experimental Yersinia pseudotuberculosis Infection

摘要

Pseudotuberculosis, caused by Yersinia pseudotuberculosis, occurs frequently in birds kept in aviaries. Disease has been described in almost all groups of birds, including canaries. Outbreaks of pseudotuberculosis, caused by Yersinia pseudotuberculosis, are most common in captive birds in winter and spring. The source of infection is generally thought to be food contaminated by feces of wild rodents and birds. The clinical picture ranges from acute septicemia with severe generalized symptoms, to a subclinical infection of the digestive tract. In the acute form, the pathological changes are confined to enlargement of the spleen and liver, as well as enteritis. In the subacute or chronic course, granulomatous nodules develop in the liver, spleen, kidneys, and lungs. Prevention of the disease by vaccination may be possible. Some success has been claimed in vaccinating birds at the Berlin Zoological Gardens. To the authors' knowledge, no challenge experiments have been performed on vaccinated animals.In these studies, the effect of vaccination with an inactivated autogenous vaccine against pseudotuberculosis in canaries was determined.