In-situ Raman Spectroscopy for the In-Line Crystallization Monitoring of Entacapone

摘要

The physico-chemical properties of bioactive compounds and drugs may have a dramatic impact on the therapeutic efficacy and on the manufacturing of the final dosage forms and therefore it is crucial to develop tools that will enable process understanding and control in real time. Major limitations to improve the control of physical and chemical processes arise from the lack of versatile, accurate and reliable in-line sensors. Hence, new approaches and methodologies are needed for a better quality control and higher product efficiency. These should enable a non-invasive detection of different physical and chemical transformations of the reactants and products during the production process.