Gene Therapy Targeted by Ionising Radiation Targets Both Tumour Cells and Tumour Vasculature

摘要

Radiation-inducible TNF gene therapy attacks the tumour cells as well as the tumour microvasculature, thereby expanding the therapeutic target of ionising radiation. The spatial and temporal control of gene therapy by ionising radiation avoids systemic toxicity by limiting TNF induction to the tumour bed. Investigation of highly radiation-inducible promoters linked to therapeutic agents may enhance the therapeutic ratio of ionising radiation.