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Antipyretic Action of Acetaminophen: Inhibition of the Cyclooxygenase Activity of Endothelial Cells Treated with IL-1

机译:对乙酰氨基酚的反热作用:IL-1处理内皮细胞环加氧酶活性的抑制作用

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The pharmacologic effects of acetaminophen are highly selective. Like the nonsteroidal anti-inflammatory drugs and inhibitors of prostaglandin-H-synthase-2 (PGHS-2), acetaminophen has antipyretic and moderate analgesic properties. Acetaminophen, however, exhibits little or none of the anti-inflammatory or antiplatelet effects nor the gastrointestinal toxicity produced by the nonsteroidal anti-inflammatory drugs. This research addresses the remarkable cellular selectivity in the inhibition of prostaglandin biosynthesis by acetaminophen.
机译:乙酰氨基酚的药理作用是高度选择性的。与非甾体类抗炎药和前列腺素-H-合酶-2(PGHS-2)的抑制剂类似,乙酰氨基酚具有解热和中等镇痛性。然而,对乙酰氨基酚少或没有抗炎或抗血小板效应,也不是非甾体抗炎药产生的胃肠毒性。该研究通过对乙酰氨基酚抑制前列腺素生物合成的抑制作用显着的细胞选择性。

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