Attenuation Factor Determination for a Vapor Intrusion Study at a Pharmaceutical Manufacturing Facility in Brazil

摘要

Background/Objectives. A pharmaceutical manufacturing facility has volatile organic ompound (VOC) impacted groundwater, whose main substances trichloroethylene (TCE), cis-1,2-dichloroethylene (cis-1,2-DCE), 1,1-dichloroethylene (1,1-DCE), vinyl chloride (VC), toluene, xylenes, ketones (methyl isobutyl ketone and acetone), methanol and total petroleum hydrocarbons (TPH). The compounds of potential concern (COPC) from a vapor intrusion (VI) perspective are TCE, VC and xylenes. Site specific target levels (SSTLs) were calculated during a human health risk assessment (HHRA). TCE and xylenes exceeded the SSTL for inhalation of vapor in enclosed spaces and VC concentrations exceeded the SSTL for inhalation of vapor in open and enclosed areas. This study will contribute to populate an internal database of attenuation factors developed for Brazil. The purpose of this evaluation was to gain a better understanding of the potential for TCE, VC and xylenes vapor intrusion in one production building, a warehouse area, and in an open area, so that appropriate risk management decisions can be made to address this potential pathway.