DYE-FUNCTIONALIZED Fullerenes for Applications in Nanobiotechnology

摘要

Introduction Since their first discovery fullerenes take one of the first places in the research of modern nanoscience concerning carbon materials. They show attractive photochemical, electrochemical and physical properties combined with a high scope for derivatization. These properties make them potential agents in biological and medicinal applications. To understand the influence of fullerene based drugs on biological systems it is important to pursue the fullerene interaction with cell membranes. Since C_(60) has not appropriate fluorescence properties for the detection in biological systems itself the functionalization of fullerenes with fluorescent dyes as e.g. fluorescein-5-isothiocyanate or disperse yellow is important. These dyes are distinguished by a characteristic fluorescence range and a well-defined detectabi-lity for measurements in biological applications. The focus of our work is the synthesis of dye functionalized fullerenes and the optimization of their water solubility. Fulleropyrro-lidine compounds, C_(60)-PCBM and its derivatives are the starting materials for the functionalization [1,2].