The new results of systematic studies of paracetamol adsorption on closed, commercially available, unmodified carbon nanotubes are presented. The results of thermal analysis, static adsorption measurements as well as the comparison with phenol adsorption data lead to suggestion about the formation of paracetamol nanoaggregates in the interstitial spaces bewteen nanotubes. This effect was next confirmed by the results of (performed in two ways) independent dynamic measurements, as well as by molecular dynamics simulation data. Next we show that the behaviour of adsorbed paracetamol during heating leds to the creation of a new drug delivery system. The type of applied nanotubes as well as the parameters of this process (called hot-melt drug deposition) influence the drug delivery process. Thus we conclude that confined nanoaggregate formation, as well as hot-melt deposition should be promising effect in preparation of highly effective, new drug delivery systems.
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