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The influences of lipid and protein concentration on wear of ultra-high molecular weight polyethylene

机译:脂质和蛋白质浓度对超高分子量聚乙烯磨损的影响

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The influence of lipid and proteins on the wear behaviour of ultra-high molecular weight polyethylene (UHMWPE) used in joint prostheses was examined by using multidirectional sliding pin-on-plate wear testers. In vivo wear behaviour of polyethylene components should be controlled to maintain the joint performance throughout the entire life cycle of artificial joints. However, there are many uncertainties about the wear mechanism of UHMWPE, especially about the effect of physiological environment. The physiological environment contains various kinds of biological molecules, such as proteins and lipids etc. These molecules can be entrained into a contact zone and possibly affect the friction and wear process of artificial joints. The aim of the current study is to examine the effects of proteins and lipids on the UHMWPE wear behaviour for better understanding of in vivo polyethylene wear process. The wear behaviour of UHMWPE on a stainless steel sliding pair for joint prostheses was evaluated by using our multidirectional sliding pin-on-plate wear testers, which can make a multidirectional sliding pathway similar to that of hip joint prostheses. Several phosphate buffered saline (PBS) solutions containing a synthetic lipid, dipalmitoyl phosphatidylcholine (L-α-DPPC), and two kinds of serum proteins, albumin and γ-globulin, were prepared. These solutions were used as lubricants in the wear test and the effect of the lipid and protein concentration on the UHMWPE wear was evaluated. Results of this study indicated that the wear behaviour of a UHMWPE-on-metal sliding pair was clearly affected by the lipid and protein concentration. Especially, the wear amount of UHMWPE increased significantly by increasing the γ-globulin concentration. Lipid could play a role of boundary lubricant and reduced wear of UHMWPE, if the protein content was significantly low. On the other hand, the polyethylene wear amount was increased with increasing lipid concentration in the case of relatively high protein concentration.
机译:通过使用多向滑动销衬垫磨损测试仪检查脂质和蛋白质对关节假体使用的超高分子量聚乙烯(UHMWPE)的磨损行为的影响。应控制聚乙烯组分的体内磨损行为,以维持在人工关节的整个生命周期中的关节性能。然而,关于UHMWPE的磨损机制存在许多不确定性,特别是关于生理环境的影响。生理环境含有各种生物分子,例如蛋白质和脂质等。这些分子可以夹带在接触区中并可能影响人工关节的摩擦和磨损过程。目前研究的目的是研究蛋白质和脂质对UHMWPE磨损行为的影响,以便更好地理解体内聚乙烯磨损过程。通过使用我们的多向滑动销盖板磨损测试仪评估用于关节假体的不锈钢滑动对的UHMWPE在不锈钢滑动对上的磨损行为,这可以制造类似于髋关节假体的多向滑动路径。制备了几种含有合成脂质,二硫代磷脂酰基胆碱(L-α-DPPC)和两种血清蛋白,白蛋白和γ-球蛋白的几种磷酸盐缓冲盐水(PBS)溶液。这些溶液用作磨损试验中的润滑剂,评价脂质和蛋白质浓度对UHMWPE磨损的影响。该研究的结果表明,UHMWPE-金属滑动对的磨损行为明显受脂质和蛋白质浓度的影响。特别是,通过增加γ-球蛋白浓度,UHMWPE的磨损量显着增加。如果蛋白质含量显着低,脂质可以发挥边界润滑剂和uhmwpe磨损的作用。另一方面,在相对高的蛋白质浓度的情况下,随着脂质浓度的增加而增加聚乙烯磨损量。

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