Production and quality assurance of cyclotron produced iodine-124 from enriched tellurium targets

摘要

The production of iodine-124 and the formulation of specific radiopharmaceuticals are an important component of the Positron Emission Tomography Program at Memorial Sloan-Kettering Cancer Center. Preparation of iodine-124 using the CS-15 cyclotron employing the (p,n) nuclear reaction on the enriched ~(124)TeO_2 solid target has been initialed. The radioidodine is isolated by a dry distillation technique from the target matrix. The mass and oxidation states of iodine species isolated from the processing were analyzed using high pressure liquid chromatography. Employing a C-8 ceverse-phase column (1) and isocratic elution conditions, the chemical purity and specific activity of the various radioiodine species was determined. The method provides a routine means for evaluation of the purity of the radioidide prior to and post radiolabeling essential for the efficient utilizatioin and recovery of this important radionuclide.