Treatment of osteomyelitis by using antibiotic-loaded porous ceramic

摘要

Porous hydroxyapatite block)HAB) could be used as a sustainer of antibiotics or anticancer drugs because of its interlinked pore structure. HAB was mixed with an antibiotic solution and decompressed in vacuum container under from 5 to 10 in. (127 mm-254 mm) Hg/20 min. to load antibiotics into HAB-pores. Twenty-one patients with osteomyelitis including one with tuberculosis and 5 patients with infected joint replacement had been treated in combination with intravenous injection. On follow up study (from 8 to 85 months; averaged 41.5 months), all of the foci had completely healed primarily by the end of the follow-up period except a case which was used on the open tibial fracture with a plate fixation. These new methods are simple, can be performed safely to treat osteomyelitis as a one stage operation.