Drug transfer to cutaneous vein in iontophoretic percutaneous absorption

摘要

Iontophoresis has been studied as a physical technique to enhance percutaneous absorption of a drug. The measurement of drug concentration in systemic circulation is usually performed using a conventional method to evaluate iontophoretic percutaneous absorption in vivo. However, drug concentrations in systemic circulation are so low that it is often below the detection limit, due to disposition processes in a body: deposition, metabolism and elimination.