Simulation Tool for the Prediction of Compound Dependence of CW-Photoacoustic-based Sensor using Dual Differential Optical Excitation

摘要

Towards the development of a sensor dedicated to noninvasive and continuous blood glucose level monitoring, we developed a protocol called optical power balance shift based on a continuous-wave photoacoustic technique using a dual differential wavelength excitation sequence. In order to optimize the sensor response, we showed using an analytical model that the OPBS response depends exclusively on the absorption coefficients at the two wavelengths. Then, using a standard near-infrared spectrophotometer, we measured the dependence of relative absorption coefficients On glucose and albumin concentrations and temperature, and built a simulation tool covering all the possible combinations of the two wavelengths from 1300 to 2500 nm. The model was validated by good agreement when compared with experimental results for the 1382/1610 nm combination.