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Flow cytometry analysis of glass - reinforced hydroxyapatite - induced changes in cell proliferation and function

机译:玻璃增强羟基磷灰石诱导细胞增殖变化的流式细胞术分析

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Glass-reinforced hydroxyapatite (GR-HA) composites have been developed in order to improve the mechanical properties of HA for use in orthopedic and dental surgery. However, the precise biological effects of these implant materials on host cells are not yet known. In this study we found, using flow cytometry (FCM), that GR-HA caused a decrease in the size of osteoblast-like MG63 cells and also resulted in a low level of inhibition of cell growth, possibly by delaying the progression of the cells from the G0/G1 into the S phase of the cell cycle.
机译:已经开发出玻璃增强羟基磷灰石(GR-HA)复合材料,以改善HA的机械性能,用于矫形和牙科手术。然而,这些植入物在宿主细胞上的精确生物学效应尚不清楚。在该研究中,我们发现使用流式细胞术(FCM),GR-HA导致成骨细胞样MG63细胞的大小降低,并且还导致细胞生长的抑制水平,可能是通过延迟细胞的进展从G0 / G1进入细胞周期的S期。

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