Hydrocortisone induces a formation of basophilic granules in the human leukemia cell line KU812

摘要

The human leukemia cell line KU812 exhibits a potential to differentiate into basophilic cells and has been described as a basophilic precursor cell line (1-6). KU812 cells produce inflammatory mediators such as histamine and arachidonic acid metabolites. In addition, the cell line expresses high affinity IhE receptor(Fc#epsilon#RI) which is central to an allergic responses, but formation of cytoplasmic granules has not been accomplished. When basophilic differentiation was indeced in basophilic lineage cells. The synthesis of inflammatory mediators are increased and granulated cells are appeared in culture.