BIPOLAR STRATEGIES IN MEDICINE (AND OTHER FIELDS) WITH THE MODEL FOR THE REGULATION OF AGONISTIC ANTAGONISTIC COUPLES

摘要

In order to understand why bipolar therapies have to be taken into account, we ought to recall the phenomena which fall under the concept of pathological homeostasis (PH) (or pathological autonomy). So, in a couple of antagonistic agents, the already prevalent one may increase even more so that it could cancel the therapeutic effect of the administered opposite agent. PH is also defined as a change in the norms of cell regulation or of great regulation systems in the body. For this occurrence to be avoided, experimental researches, design of a mathematical model [the model for the regulation of agonistic antagonistic (AA) couples] made easier to perform therapeutical strategies combining AA agents, noticeably by using the vasopressin-corticosteroids couple for some diseases where the escape from the expected action of corticosteroids is usual. Paradoxical use of only one agent was also considered. Bipolar therapies (BPT) represent, in our opinion, the only possible way for improving some pathological states, when unipolar therapies fail. Before setting the main rules and the already obtained results of BPT, we need to speak about a crucial phenomenon, this of 'pathological homeostasis' (PH).