Data Associated with Epigenetic Changes Brought by SARS-Cov-2 : Enlightment on the Treatment and Public Health Practices

摘要

In this year, COVID-19 and Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) became a major public health issue. After countless researchers' efforts, many biological properties of SARS-Cov-2 and infection pathways have been deciphered. Nevertheless, there are currently many unresolved issues. For instance, the disparity between the severity of the symptoms brought by SARS-Cov-2 is one of these issues. Because it is believed that many biological pathways are the results of the interplay between genetic and epigenetic pathways, this article seeks to explain the these unsolved issues by analyzing the data associated with hosts' epigenetic regulation. Considering the importance of Angiotensin converting Enzyme 2 (ACE2) and the frequent presence of comorbidities in critically ill patients, the article hypothesizes that it is the comorbidities that bring the changes in host epigenome and cause a severe form of COVID-19. The purpose of this paper is to make a thorough inquiry about whether the comorbidities bring he changes in host epigenome and cause a severe form of COVID-19. After randomly searching and analyzing many data papers, many evidences are found to support this idea. Therefore, this paper hypothesizes that it is the comorbidities cause the changes in host epigenome and exacerbates the symptoms led by COVID-19. Based upon this hypothesis, there are many potential treatment options and implications to the public health system.