Network component analysis of Saccharamyces cerevisiae stress response

摘要

A method, network component analysis, was developed for uncovering hidden regulatory signals from outputs of networked systems, when only partial knowledge of the underlying network topology is available. This method was successfully applied to microarray data of yeast Saccharamyces cerevisiae under various stress conditions. The activities of 96 transcription factors were determined, which differ significantly from their gene expression patterns.