Stomach Cancer Detection through Exhaled Breath using Biomarkers Analysis

摘要

Normally, when a person is affected by a disease, there is an imbalance in their metabolic system that causesa change in the behaviour of their body.In the case of a person affected by cancer or gastric diseases, the presence of the specific volatile metaboliteshas been exposed for them, which are useful as markers and allows the early diagnosis of these diseases,which facilitates the adaptation of treatments for the prevention, diagnosis and cure of patient.By using of the gas chromatography it is possible to realize a qualitative and quantitative analysis of thecomposition of breathing in healthy people or with cancer, which allows to identify biomarkers, so it could be adiagnostic method for such diseases, with the advantages to discriminative rapidly, safety way with a noninvasivemethod for the early detection of the disease, which can be applied for screening tests to be carriedout on populations at risk.This study describes a methodology for the gastric cancer detection through biomarkers in Colombianpatients. For the validation of the results obtained, 30 measures were taken from the volunteers, which werestored in Tenax tubes; then they were analysed with a gas chromatography and mass spectrometryequipment. On the other hand, a set of 7 compounds (biomarkers) was found through the analysis of GC-MS,which were related to the metabolism of patients with gastric cancer (GC) and control (C).