Nanodiamond based complexes for prolonged dexamethasone release

摘要

In the article for the first time the properties of nanodiamond complexes with dexamethasone obtained by two differentapproaches - attachment of the drug to the surface of nanodiamond and to the nanodiamond, covered by silica layer –were compared. It was found that the synthesized nanocomposite ND@silica@Dex is able to retain a greater amount ofdrug and allows achieving prolonged release of dexamethasone. These properties of the complexes ND@silica@Dexprovide prospects for their use as drug carries.