Study on the Biochemical Nanoparticles for Bio-imaging and Molecular Diagnostics of Alzheimer's Disease

摘要

Alzheimer's disease (AD) is characterized by its step by step deterioration with periods of stability, punctuated with rapid decline in cognitive function. Such deterioration involves the loss of neurons and synapses in the cerebral cortex and certain subcortical regions of the brain.This loss causes gross atrophy of the affected regions; which includes degeneration of the temporal and parietal lobe, parts of the frontal cortex and cingulate gyrus, and eventually a reduction in the respective regions of the brain.In this paper, computational biomedical simulation technology was provided as an alternative method for a solution of AD treatment. A potential solution in applications-related nanotechnology was presented using nano fullerene complexes and EDTA molecules due to their ability to virtually attach large quantities of proton H. Multiple pathways through oxidative stress can produce cell injury in the human brain.A free-radical chain reaction capable of propagating in space is the major oxidative reaction in bio-membranes in the human brain’s nerve system. To find active energy, stability, and efficiency, various clusters of compounds were created and optimization configuration energy was collected. While there was a trend of increase in enthalpy with increasing the chain of the molecules, variation of energy was also observed. The goal of these studies on the role of oxidative stress that plays in the degeneration of nerve cells is how the nano-scaled chemical antioxidants may be useful in the treatment of AD.