Modification of the ASTM Platelet and Leukocyte Assay - Use of an Alternative and Clinically Relevant Anticoagulant: An In-vitro Hemocompatibility Assessment of Blood Contacting Medical Devices

摘要

The purpose of this test method is to assist in the determination of the thrombogenic potential of medical materials exposed to human whole blood. By evaluating surface-induced activation, platelet adherence to a material, and platelet and leukocyte depletion from blood, a material's potential for thrombus formation can be assessed. If a significant decrease in platelets and/or leukocytes is observed in whole blood when compared to a blank control, the tested material has the potential to induce an in-vivo thrombogenic response.