Non-linear Multiphysic Numerical Study of Bone Tumor Hyperthermia Using Magnetic Biomaterials

摘要

This work deals with the non-linear and multiphysic modeling of the hyperthermia treatment of bone tumors using novel biomaterials loaded with magnetic nanoparticles. The possible treatment of Osteosarcoma tumor with magnetic hydroxyapatite and poly-caprolactone doped with magnetite nanoparticles are analyzed. During the procedure, the materials and tissue physical properties modifies due to the heating, implying a coupled solution of thermal and electromagnetic equations. In the present study a numerical model, implemented using a commercial finite element software, is developed to include the intrinsic non-linearities of the hyperthermia multiphysic treatment. Therefore, an accurate in silico analysis is performed to identify the strength and frequency of the external magnetic field which would ensure an effective therapy, evaluated using the thermal dose damage analysis.