Core-shell Silica-coated Iron Oxide Nanoparticles for Magnetic Hyperthermia

摘要

We report the synthesis and characterization of silica-coated iron oxide nanoparticles with a core-shell structure for magnetic hyperthermia. The nanoparticles of silica-coated iron oxide were synthesized using the reverse micelle method. The coating of the silica was performed simultaneously with the synthesis of the nanoparticles. The as-synthesized silica-coated iron oxide nanoparticles exhibited superparamagetic properties with a saturation magnetization of 48.8 emu/g. The inductive heating ability of the nanoparticles dispersed in water with a concentration of 20 mg/ml was investigated in a 1.03-kA/m, 260-kHz alternating magnetic field. The results revealed a heat release of up to 139 W per one gram of iron, demonstrating the potential application of the nanoparticles in magnetic hyperthermia.