A Hybrid Cardio-Pulmonary Simulation Platform-An Application for Extracorporeal Assist Devices

摘要

U.S.Food and Drug Administration agency is encouraging to use modeling and simulation in medical device evaluation,in order to reduce validation process and reduce a number of animal and human trials.To address this challenge,a variety of models and simulators is developed,playing the role of artificial/virtual patients or animals.There is a lack of simulators enabling interaction with real extracorporeal devices and also offering more advanced models of the cardiovascular/respiratory systems,available in pure computer simulators.A previously elaborated hybrid(hydro-computer),cardio-pulmonary simulation platform was adapted for extracorporeal applications.An extracorporeal membrane oxygenation(ECMO)mechanical assistance was simulated using this simulation platform and specially designed hydraulic model of ECMO.In these simulations veno-arterial(V-A)and veno-venous(V-V)basic ECMO configurations were considered.The preliminary results demonstrate the left ventricular afterload increasing for V-A configuration and blood recirculation effect for V-V one.Taking into account cannulas position,geometrical structures of the systemic vessels and real oxygenation gives more realistic and prospective approach.The application for extracorporeal assist devices(like ECMO)extends the whole hybrid cardio-pulmonary simulation platform functionalities in terms of the heart and lungs assistance simulations.The configuration for cardio-pulmonary bypass is also possible to be introduced.This simulation platform is a flexible tool and can be used by a wide range of stakeholders as a test-bench for various medical assist devices,as well as for educational purposes.