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Tuning an Activator-Repressor Clock Employing Retroactivity

机译:调整采用逆合行的激活器 - 阻遏钟

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Activator-repressor systems have been shown to be capable of oscillations and are therefore an important clock motif in the field of Synthetic and Systems Biology. In this paper, we propose a method to regulate oscillatory behavior in such systems by the addition of DNA binding sites for the proteins involved in the clock network. We show that the retroactivity effect caused by this addition can effectively change the relative timescales among the protein dynamics and impact the behavior of the clock. We also employ root locus analysis to obtain a graphical interpretation of the results.
机译:活化剂 - 阻遏物系统已被证明能够振荡,因此是合成和系统生物学领域的重要时钟图案。在本文中,我们提出了一种通过添加参与时钟网络中的蛋白质的DNA结合位点来调节这种系统中的振荡行为的方法。我们表明,由该加法引起的追溯效应可以有效地改变蛋白质动力学之间的相对时间表并影响时钟的行为。我们还采用了根轨迹分析来获得结果的图形解释。

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