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Towards high density biosensors for mobile diagnostics

机译:迈向用于移动诊断的高密度生物传感器

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Research studies in medicine, genetics and process monitoring technology generally go together with advances in nano-engineering. Furthermore, advances in engineering, control and automation on the nano scale first enable so far impossible studies in molecular and cellular biology. This fruitful interaction leads to the design and development of new setups and methods, which push the boundaries for possible experiments in the area of handling and manipulation of biomaterials. In our paper the latest work on two areas of this research focus is shown. 1) Within the last years, the AFM was used for the handling and manipulation of biomaterials. However, the automation to use the AFM for industrial processes needs a robust and accurate automation. In this paper we also present the latest work on the automation of AFM based methods. 2) In the future, mobile diagnostics will become more and more important. To enable robust, fast and precise systems, new methods for the design and structuring of the necessary bio-components are needed. For this, a possible approach to structure bio-components from several nm up to a few μm is presented in this paper as well. 3) First simulations and principles for the design of a new signal acquisition unit are shown, to set up diagnostic systems without complex optical setups or fluorescence dyes.
机译:在医学,遗传学和过程监控技术方面的研究通常与纳米工程学的进步相结合。此外,纳米级工程,控制和自动化技术的进步首先使得迄今为止在分子和细胞生物学上不可能进行的研究成为可能。这种卓有成效的互动导致了新设置和方法的设计和开发,这为生物材料处理和操纵领域中可能进行的实验开辟了边界。在我们的论文中,显示了该研究重点两个领域的最新工作。 1)在过去的几年中,原子力显微镜被用于处理和操纵生物材料。但是,将AFM用于工业过程的自动化需要强大而准确的自动化。在本文中,我们还介绍了基于AFM的方法的自动化方面的最新工作。 2)未来,移动诊断将变得越来越重要。为了实现健壮,快速和精确的系统,需要新的方法来设计和构造必要的生物组件。为此,本文还提出了一种可能的方法来构造从几纳米到几微米的生物成分。 3)显示了用于设计新信号采集单元的第一模拟和原理,以建立诊断系统而无需复杂的光学设置或荧光染料。

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