Selective release system for biosensors for tumor tissues and tumor therapeutics, biosensors for tumor diagnostics

摘要

The present invention relates to a local release system of sensors for tumor tissue and therapeutic / diagnostic agents for target tumor treatment and diagnosis. More specifically, the invention relates to cation-stabilized biopolymer gels, in particular alginate gels, which can be used as carrier matrices for tumor therapeutics and / or tumor diagnostics, wherein the gels are produced by tumor cells or tumor tissues. Stimulation, in particular under lysyl oxidase (LOX), characterized in that the tumor therapeutic agent and / or tumor diagnostic agent may be released. The invention also relates to a pharmaceutical composition comprising a incorporated tumor therapeutic or tumor diagnostic agent and optionally a cationic stabilized biopolymer gel with additional reporter material. One aspect related to the present invention relates to an in vitro method for detecting the presence and / or amount of a tumor specific product in a patient's body, the blood, urine, feces of a patient administered with the pharmaceutical composition according to the present invention. The same physiological sample is characterized by the presence and amount of reporter material released after destabilization of the gel due to contact with the tumor specific material to be detected and optionally compared to a reference value.