首页> 外文会议>ASME summer bioengineering conference;SBC2012 >THERMAL EFFECTS ON OSTEOGENESIS OF HUMAN MESENCHYMAL STEM CELLS
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THERMAL EFFECTS ON OSTEOGENESIS OF HUMAN MESENCHYMAL STEM CELLS

机译:热作用对人间充质干细胞成骨的影响

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Intensive studies were reported on the osteogenesis of mesenchymal stem cells (MSC) using chemicals and mechanical loading. However, the maturity of differentiated osteoblasts is not same as that of isolated adult osteoblasts. Thermal treatment could be a missing factor in stem cell differentiation. It was reported that mild heat stimulated bone growth in animal experiments [1-2]. Thermal treatment is also used as a therapy to promote bone repair after injury [3]. In addition, hot shower daily is recommended to osteoarthritis patients. However, the mechanisms for the heat-induced osteogenesis are not completely known and the thermal regulation of human mesenchymal stem cells (hMSCs) differentiation is not well studied. In this study, the direct effects of mild heat shock (HS) on the differentiation of hMSCs into osteoblasts in self-assembling peptide hydrogel were investigated.
机译:在利用化学品和机械负载的情况下报告了在间充质干细胞(MSC)的骨质发生上进行了集约化研究。然而,分化的成骨细胞的成熟与分离的成人成骨细胞的成熟不相同。热处理可能是干细胞分化的缺失因子。据报道,动物实验中的温和热刺激骨生长[1-2]。热处理也用作促进损伤后骨修复的疗法[3]。此外,建议热淋浴到骨关节炎患者。然而,对热诱导的骨发生的机制不完全已知并且对人间充质干细胞(HMSCs)分化的热调节不受很好地研究。在该研究中,研究了轻度热休克(HS)对自组装肽水凝胶中HMSCs进入成骨细胞分化的直接作用。

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