Characterization by magnetophoresis of therapeutic microcarriers relying on embedded nanoparticles to allow navigation in the vascular network

摘要

In this paper a magnetophoretic chamber design is presented as a tool to evaluate the deflection patterns of magnetic microcarriers compatible with Magnetic Resonance Navigation (MRN) for drug delivery applications. Such micro-entities with different magnetic characteristics and subject to the force of a fluid flow show different deflection patterns while the effects of aggregations under different fluid flow velocities are critical to estimate the most adequate MRN strategy. Preliminary results indicate that the system and the corresponding methods presented here could become a practical tool to characterize the magnetophoretic behaviors of such microcarriers intended for navigation in the vascular network.