ESTIMATION OF ERYTHROCYTE DEFORMABILITY USING A VISCOELASTIC MODEL WITH TWO DEGREES OF FREEDOM

摘要

An erythrocyte is represented using a viscoelastic model with two degrees of freedom, where a spring was connected parallel to a dashpot to estimate quantitatively the dynamic de-formability. To identify such parameters as the elastic modulus and viscous damping coefficient of the model, erythrocytes were deformed using a periodical shear flow field. Displacement of the center of gravity △G and the deformation quantity of major axis △L were obtained from time series of images. In this paper, erythrocytes from a normal subjects were treated with glu-taraldehyde to create variations in hardness and deformability. Both of the data series are periodic on movement and deformation of erythrocytes. Based on the experimental data, parameters of the viscoelastic model were identified. The estimation method of dynamic deformability of erythrocytes was examined.