ENHANCED TRANSMUCOSAL TRANSPORT USING OSMOLYTE-MEDIATED FLUID-MATRIX INTERACTION

摘要

Various drug delivery systems are developed to deliver therapeutic and diagnostic agents to tissues covered with mucus, such as airways, nasal cavity, or oral cavity [1]. However, the mucus, which present for protection of the tissues, significantly hinders the transport of these agents and ultimately mitigates their efficacy [2]. Several studies have been performed to improve the transmucosal transport by studying the transport rates of polymeric nanoparticles with various sizes and surface chemistry [3-5]. However, drug delivery systems with improved transmucosal transport capability are still highly desired.