Detection of organ dysfunction in type II diabetic patients

摘要

Type II diabetes mellitus is characterized by several abnormalities in different body organs such as the pancreas, the liver, muscles and adipose tissues. We have developed a technique to detect the dysfunction of different organs in a group of type II diabetic patients. The detection of these abnormalities is performed through euglycemic insulin clamp and hyperglycemia clamp applied to a type II diabetes model developed in our previous work [1]. Since the peripheral insulin and glucose concentrations are the only common clinical measurements, we have used a particle filtering algorithm to estimate the insulin and glucose concentrations in different parts of the body. These concentrations reflect the pancreatic insulin secretion rate as well as the glucose metabolic rates in the liver, muscles and adipose tissues which represent the functional behavior of the corresponding organs. Our results show that the proposed technique is capable of detecting deficiencies in the pancreatic insulin production, the peripheral glucose uptake, endogenous glucose production and hepatic glucose uptake rates. The information provided by the algorithm can, therefore, be used to choose a suitable dietary program and/or prescribe an efficient medication for type II diabetic patients.