Study on Membrane Protein Interaction Networks by Constructing Gene Regulatory Network Model

摘要

At present, about a quarter of all genes in most genomes contain transmembrane (TM) helices, and among the overall cellular interactome, helical membrane protein interaction is a major component. Interactions between membrane proteins play a significant role in a variety of cellular phenomena, including the transduction of signals across membranes, the transfer of membrane proteins between the plasma membrane and internal organelles, and the assembly of oligomeric protein structures. However, current experimental techniques for large-scale detection of protein-protein interactions are biased against membrane proteins. In this paper, we construct membrane protein interaction network based on gene regulatory network model. GRN model is proposed to understand the dynamic and collective control of developmental process and the characters of membrane protein interaction network, including small-world network, scale free distributing and robustness, and its significance for biology. The proposed method is proved to be effective for the study of membrane protein interaction network. The results show that the approach holds a high potential to become a useful tool in prediction of membrane protein interactions.