Measurement of kurtosis in renal apparent diffusion coefficient and the limitation of mono-exponential model for quantification

摘要

Conventional diffusion tensor imaging (DTI) measures water diffusion parameters base on a gaussian function. However, water movement in biological tissue is often non-gaussian and the non-gaussian behavior contain useful information related to tissue structure. This study is using the kidney of normal volunteers' image to demonstrate the biexponential model. The kurtosis can denote the extent non-gaussianity of renal diffusion, so we use the many set of b-values to calculate the mean kurtosis image.