Electrophysiology research on striatum neurons after exercise-induced fatigue

摘要

Exercise-induced fatigue is a complex phenomenon involving the central nervous system (CNS) and muscle. In CNS, striatum is one of the key basal ganglia components which controls planning and execution of motor behaviors. The purpose of this study was to determine the influence of exercise-induced fatigue on striatum neuron's excitability. 56 rats were divided into control group (CG) and fatigue group (FG).10-day load- increasing swimming method was used to set up exercise-induced fatigue animal model. Rats' body weight and chemical indexes (CK&BU) were monitored. Extra cellular microelectrode recording technique in vivo was used to record striatum neurons spontaneous firing. In CG, high discharge frequency neuron's percentage is only 6% while in FG it increased to 19% (P<0.05); in CG we recorded regular firing, irregular firing, and regular-irregular firing styles, while in FG we recorded not only these three styles but also special regular bursting firing style; in FG the high frequency neurons are mainly focused in the dorsolateral part of striatum. Excitability of striatum neurons changed after exercise-induced fatigue. High frequency firing neuron's percentage increased significantly. Bursting firing of the striatum neuron may the special modulate pattern for motor function during the status of fatigue.