Electroporation is an elegant technique used for proliferation control in Cancer cells. This budding mode of therapy called electrochemotherapy uses electrical pulses and chemodrugs to trigger cell death in cancerous cells. The efficacy of this technique depends on a variety of factors including electric field intensity, pulse duration and the number of pulses. In this study, Human cervical (ME180), Human Acute Myeloid Leukemia (KG1) and Human Promyelocytic leukemia (HL60) cancerous cell lines were subjected to electroporation in the presence of 1μM Bleomycin at 1200 V/cm, 100μs; 450 V/cm, 25ms; and 200 V/cm, 40ms. The energy applied and charge delivered with each pulse are also calculated. The results indicate that with increase in energy delivered, there in increase in cell death. This promises to be a very useful tool in for the treatment of patients suffering from chemo-refractive tumors.
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机译：电穿孔是用于控制癌细胞增殖的一种优雅技术。这种称为电化学疗法的崭新疗法模式使用电脉冲和化学药物来触发癌细胞的细胞死亡。该技术的有效性取决于多种因素，包括电场强度，脉冲持续时间和脉冲数。在这项研究中，将人类宫颈细胞（ME180），人类急性髓细胞白血病（KG1）和人类早幼粒细胞白血病（HL60）癌细胞系在1μM博来霉素存在下于1200 V / cm，100μs进行电穿孔。 450 V / cm，25毫秒;和200 V / cm，40ms。还计算了每个脉冲施加的能量和传递的电荷。结果表明，随着传递能量的增加，细胞死亡也增加。这有望成为治疗患有化学折射性肿瘤的患者的非常有用的工具。
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