This paper gives the best method that combines the layer analysis method and algorithms of DIJKSTRAS to make decision of distribution route of supply chain. It used the layer analysis method to establish the layer structure model, analyzed factor which will affect the decision of the distribution route .To determine various price factor, we could solve each price of distribution route .In the searching process, the most important part of DIJKSTRA is how to determine the distribution price .We could take the price as the price of the shortest route problem, and then the DIJKSTRA Algorithms way will give the superior distribution route in a comprehensive function.
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