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Development of a New Monte-Carlo Treatment Planning System for Boron Neutron Capture Therapy

机译:硼中子捕获疗法的新型蒙特卡洛治疗计划系统的开发

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To improve treatment planning in boron neutron capture therapy (BNCT), a new Monte-Carlo radiotherapy planning system is under development at Japan Atomic Energy Agency (JAEA). This system (developing code: JCDS-FX) builds on fundamental technologies of JCDS (JAEA Computation Dosimetry System) which has been applied to actual BNCT trials at Japan Research Reactor No.4 (JRR-4). Basic technologies of JCDS have been taken over to JCDS-FX, and some new functions have been built into the system. One of features of the JCDS-FX is that PHITS as a multi-purpose particle Monte-Carlo transport code has been applied to particle transport calculation. Application of PHITS enables to evaluate doses for neutrons and photons as well as protons and heavy ions. Therefore, the JCDS-FX with PHITS can perform treatment planning for not only BNCT but also particle radiotherapy.To verify calculation accuracy of the JCDS-FX with PHITS, dose evaluations for neutron irradiation of a cylindrical water phantom and for an actual clinical trial conducted at JRR-4 were performed. The verification results indicated that JCDS-FX is applicable to BNCT treatment planning in practical use. Further verifications of the system are being performed to achieve practical application of the system in the future. And in addition to the BNCT, investigations for application of the system to any other particle radiotherapy like proton therapy are carried forward.
机译:为了改善硼中子俘获治疗(BNCT)的治疗计划,日本原子能机构(JAEA)正在开发一种新的蒙特卡洛放射治疗计划系统。该系统(开发代码:JCDS-FX)基于JCDS(JAEA计算剂量系统)的基本技术,该技术已应用于日本4号研究堆(JRR-4)的实际BNCT试验中。 JCDS的基本技术已被接管到JCDS-FX,并且一些新功能已内置到系统中。 JCDS-FX的功能之一是PHITS作为多用途粒子蒙特卡洛传输代码已应用于粒子传输计算。 PHITS的应用可以评估中子和光子以及质子和重离子的剂量。因此,带有PHITS的JCDS-FX不仅可以执行BNCT的治疗计划,而且还可以执行粒子放射治疗。 为了验证带有PHITS的JCDS-FX的计算精度,对圆柱形水体模的中子辐照剂量进行了剂量评估,并在JRR-4上进行了实际临床试验。验证结果表明,JCDS-FX适用于实际使用中的BNCT治疗计划。正在对该系统做进一步的验证,以实现将来该系统的实际应用。除BNCT之外,还进行了将该系统应用于质子治疗等其他任何粒子放射治疗的研究。

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