ELECTROMAGNETIC FIELD MEDIATES CAPILLARY-LIKE NETWORK FORMATION VIA MAPK/ERK SIGNALING CASCADE

摘要

Abnormal angiogenesis (formation of capillaries) plays an important role in the impaired diabetic wound healing and has emerged as a new target area for therapeutic interventions. Pulsed magnetic field therapy, which was initially used for healing of bone fractures, has been recently introduced as a potential therapy to treat diabetic and chronic wounds [1], although the mechanisms responsible for improved healing are still unclear. Electromagnetic fields (EMF) have been shown to act as a directional cues in cellular responses such as migration and activations of several signal transduction cascades [2].