Neural prostheses often suffer from undesired chronic inflammatory tissue response. Therefore; a sensitive and real-time biosensor for inflammatory cytokine detection would provide invaluable information toward solving this problem. Such a biosensor based on an aptamer probe doped in polypyrrole and subsequent electrochemical impedance spectroscopy (EIS) has been developed. PDGF, an important inflammatory cytokine, has been successfully measured in both offline EIS characterization and real-time impedance monitoring. For in situ detection of PDGF, the best sensitivity of 10 ng/ml has been achieved.
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机译：神经假体经常遭受不希望的慢性炎性组织反应。所以;用于炎症细胞因子检测的灵敏，实时的生物传感器将为解决这一问题提供宝贵的信息。已经开发了基于掺杂有聚吡咯的适体探针和随后的电化学阻抗谱（EIS）的生物传感器。 PDGF是一种重要的炎症细胞因子，已在离线EIS表征和实时阻抗监测中成功进行了测量。对于PDGF的原位检测，已达到10 ng / ml的最佳灵敏度。
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