Detection of L-Asparagine by Surface-Enhanced Raman Scattering

摘要

In this work, Surface-enhanced Raman Scattering had been applied to detect L-Asparagine. The presence of this amino acid in tissues and fluids helps to the prevalence of acute lymphoblastic leukemia cells and promotes the proliferation of metastasis for some other malignant tumors; depletion of L-Asparagine is up to date the best treatment for leukemia and could improve the prognosis for other cancers. We have carried out the preparation and characterization of two types of metallic surfaces, one with nanoparticles and the other one with nanostructures; we obtained and compared the SERS spectra and enhancement factors between them to emphasize the advantages in each one. The principal aim of this work is to establish the basis for a new reliable biosensor capable of being used in clinical applications.