Non-invasive in-vivo Raman spectroscopic measurement of the dynamics of the antioxidant substance lycopene in the human skin after a dietary supplementation

摘要

A non-invasive optical method based on resonance Raman spectroscopy was used for the in vivo detection of the concentration of the carotenoid antioxidant substance lycopene in the human skin.The physiological variation of the level of lycopene in the skin during a 6 month period was measured daily in 7 volunteers. It was shown that all volunteers had a different individual level of lycopene in the skin, depending on the lifestyle of volunteers. It was shown that the supplementation of the foodstuffs containing lycopene, such as tomato products and some fruits, increases the level of lycopene in the skin. The increase in the lycopene level can be usually observed on the next day after the supplementation.The present results demonstrate that a diet rich in products containing a high amount of carotenoids, such as lycopene, can be an efficient strategy to increase the carotenoid level of the skin.