Development of group's signature for evaluation of skin cancer in mice caused by ultraviolet radiation

摘要

In this research effort, the effect of UVC (260 nm) on the skin of one month old Balb/c mice exposed for a total of 100 hours is studied. The goal is to identify those independent variables in the experimental group that have a significant change in their measurements in compare to the measurements of their counterparts in the control group. To meet the goal, we create signatures for both experimental and control groups using the Kohonen self-organizing map. The comparison of signatures to each other delivers the significant changes in the independent variables between the two groups. The findings are compared with another set of findings obtained from using analysis of variance. The results reveal that using signature approach that is created based on the SOM methodology, is a viable tool for this type of analysis.