TRANSDERMAL DELIVERY OF ACETAMINOPHEN FOR INFANTS AND CHILDREN: IN VITRO PERCUTANEOUS PENETRATION AND IN VIVO STUDIES IN RATS

摘要

Orally or rectally administered acetaminophen medications, a most widely used antipyretic therapy for infants and children, are not useful in cases of vomiting and diarrhea. The transdermal route of this drug administration was evaluated in skin penetration studies in vitro and in a pharmacokinetic study in rats.