L-OROS~(~R) HARDCAP~(TM): A NEW OSMOTIC DELIVERY SYSTEM FOR CONTROLLED RELEASE OF LIQUID FORMULATION

摘要

A self-emulsifying formulation (SEF) was developed for progesterone, a hydrophobic drug. In a canine pharmacokinetic study, the SEF showed six-fold enhancement of oral bioavailability. An osmotic delivery system was developed for controlled release of a progesterone suspension in the SEF.