Temperature responsive polymeric micelles for double targeting drug delivery

摘要

It is well known that poly (N-isopropylacrylamide)(PIPAAm) in aqueous solution exhibits a reversible thermo-responsive phase transition at 32 deg C(1), termed the lower critical solution temperature (LCST). PIPAAm is water-soluble and hydrophilic, exhibiting an extended chain conformation below its LCST, yet undergoing a phase transition to an insoluble and hydrophobic aggregate above the LCST. This phase transition occurs within a narrow temperature range and is reversible. Utilizing this thermo-responsive property, PIPAAm and its gels have been studied for on-off drug release (2-5), chromatography systems (6-7), and attachment/detachment of cultured cells (8-10) and temperature responsive polymeric micelles (11-15) for double targeted drug delivery.