New formulation strategies for bioavailability enhancement of two poorly absorbed phytonutrient supplements: di-indolyl methane and yohimbine bark extract

摘要

There is increasing interest in the use of promising phytochemicals as nutritional supplements. However, many candidates are only poorly soluble and can exhibit low bioavailability. Recently, a new formulation strategy has been developed that combines a number of approaches to bioavailability enhancement.~1 The strategy is to form micron to sub-micron particles of dietary phytochemicals associated with mixtures of surface-active agents that promtoe intestinal uptake. This approach has been adapted for a number of active ingredients including the cruciferous indole, diindolyl methane (DIM) and yohimbine bark extract (YBE).